2025
- A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours
Pretto S, Yu Q, Bourdely P, Trusso Cafarello S, Van Acker HH, Verelst J, Richiardone E, Vanheer L, Roshanzadeh A, Schneppenheim F, Cresens C, Sassano ML, Dehairs J, Carion M, Ismail S, Agostinis P, Rocha S, Bald T, Swinnen J, Corbet C, Lunt SY, Thienpont B, Di Matteo M, Mazzone M. Nature Metabolism - Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation
Griepke S, Grentzmann A, Tripodi GL, Hansen J, Fonseca MP, Nilsson MD, Tallouzi Y, Grupe E, Jensen PS, Beck HC, Temprano-Sagrera G, Sabater-Lleal M, Burton M, Dembic M, Thomassen M, Forteza MJ, Terp MG, Lindholt JS, Rasmussen LM, Steffensen LB, Stubbe J, Ketelhuth DFJ. Cardiovascular Research - Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo I, Mañanes D, Munné P, Núñez V, Herrera J, Catalá-Montoro M, Alvarez M, Del Pozo MA, Melero I, Wculek SK, Sancho D. Nature Communications - Cross-priming in cancer immunology and immunotherapy
Luri-Rey C, Teijeira Á, Wculek SK, de Andrea C, Herrero C, Lopez-Janeiro A, Rodríguez-Ruiz ME, Heras I, Aggelakopoulou M, Berraondo P, Sancho D, Melero I. Nature Reviews Cancer - ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance
Stüve P, Godoy GJ, Ferreyra FN, Hellriegel F, Boukhallouk F, Kao YS, More TH, Matthies AM, Akimova T, Abraham WR, Kaever V, Schmitz I, Hiller K, Lochner M, Salomon BL, Beier UH, Rehli M, Sparwasser T, Berod L. Molecular Metabolism - Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera I, Jarit-Cabanillas A, Brandi P, Martínez-López M, Martínez-Cano S, Rodrigo-Tapias M, Femenía-Muiña M, Redondo-Urzainqui A, Nuñez V, González-Correa C, Moleón J, Duarte J, Conejero L, Mata-Martínez P, Díez-Rivero CM, Bergón-Gutiérrez M, Fernández-López I, Gómez MJ, Quintas A, Dopazo A, Sánchez-Cabo F, Pariente E, Del Fresno C, Subiza JL, Iborra S, Sancho D. Immunity - Helminths target macrophage epigenetics and metabolism to evade immunity
Everts B. Trends in Parasitology - Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Sinclair LV, Youdale T, Spinelli L, Gakovic M, Langlands AJ, Pathak S, Howden AJM, Ganley IG, Cantrell DA. Nature Immunology
2024
- Understanding immunometabolism in cardiovascular disease: translating research into practice
Norata GD, Sancho D, Van den Bossche J, Ketelhuth DFJ on behalf of the European Immunometabolism Network (EIMN). European Heart Journal - Proceedings of EIMN’s 1st European Immunometabolism Conference
Ketelhuth DFJ, Desler C, Cordes T, Corrrado M, Argüello R, Everts B, Van den Bossche J on behalf of the European Immunometabolism Network (EIMN). Immunometabolism - Metabolic homeostasis of tissue macrophages across the lifespan
Wculek SK, Forisch S, Miguel V, Sancho D. Trends in Endocrinology & Metabolism - Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
Nosenko M, Anisov D, Gubernatorova E, Gorshkova E, Zeng Y-R, Ye D, Wang P, Finlay D, Drutskaya M, Nedospasov S. Journal of Leukocyte Biology - Harnessing dendritic cell metabolism for healthy ageing: reducing the risk of cardiovascular disease?
Wculek SK. European Heart Journal - Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Heras-Murillo I, Adán-Barrientos I, Galán M, Wculek SK, Sancho D. Nature Reviews Clinical Oncology