2025
- Comparison of immunometabolic profiles in whole blood versus peripheral blood mononuclear cells
Diallo I, Heieis G, Manurung MD, Cisse M, Mouwenda YD, Kruize YCM, Mbow M, Yazdanbakhsh M, Everts B. Immunometabolism - Fatty acid binding protein 2 (FATP2/SLC27A2) blockade with Lipofermata elicits dual effects on inflammatory responses in human monocytes and macrophages
Hahn N, Chornyi S, Heister D, de Vries HE, Giera M, Boon MR, Kooij G, Van den Bossche J. Immunology Letters - mTOR activity and metabolic reprogramming of CD8+ T cells is impaired under hypoxia and within the multiple myeloma bone marrow
Fulton-Ward T, Gudgeon N, Thirlwell I, Bishop EL, Marzullo B, Giles HV Dr, McIlroy G, Ferguson P, Kishore B, Rogers K, Alfasi NN, Wong T, Aytain S, Tennant DA, Pratt G, Dimeloe S. Blood Advances - Increased mitochondrial fusion via systemic OPA1 overexpression promotes dyslipidemia and atherosclerosis in LDLR deficient mice
Da Dalt L, Fantini F, Giancane G, Moregola A, Roda S, Svecla M, Pedretti S, Vingiani GB, Sun J, Edsfeldt A, Goncalves I, Uboldi P, Donetti E, Baragetti A, Mitro N, Scorrano L, Norata GD. Molecular Metabolism - Assessing the metabolic profile of CD4+ and CD8+ T lymphocytes in chronic Chagas disease patients using SCENITH
Cruz KM, Ferragut F, Flores-Santibañez F, Argüello RJ, Gómez KA. Methods in Molecular Biology - A single-cell methodology for energy metabolism analysis in parasitic protozoa
Vilchez-Larrea SC, Argüello RJ, Alonso GD. Methods in Molecular Biology - The evolving landscape of targets for lipid lowering: from molecular mechanisms to translational implications
Ballantyne CM, Norata GD. European Heart Journal - Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Denk D, Singh A, Kasler HG, … , Argüello RJ, … , Verdin E, Rinsch C, Greten FR. Nature Aging - Homeostatic control of energy metabolism by monocyte-derived macrophages
Martins R, Blankehaus B, Braza F, … , Wculek SK, Sancho D, Mallo M, Soares MP. EMBO Journal - Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga R, Li Q, Zhao Y, … , Argüello RJ, Rolhion N, Michel ML, Wai T, Sokol H. Cell Host & Microbe - L-Phenylalanine is a metabolic checkpoint of human Th2 cells
Kulkarni AJ, Rodriguez-Coira J, Stocker N, … , Argüello RJ, Barber D, Villaseñor A, Sokolowska M. Cell Reports Medicine - Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Jenkins BJ, Jenkins YR, Ponce-Garcia FM, … , Finlay DK, Sinclair LV, … , Pearson JA, Vincent EE, Jones N. Nature Communications - Production of functional CD19 CAR T cells under hypoxic manufacturing conditions
Micallef Nilsson I, Poiret T, Ryu J, Mohammadpour M, Henriksson J, Österborg A, Mattsson J, Schurich A, Magalhaes I. Frontiers in Immunology - Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
Cheung DMS, Razsolkov M, Bonacina F, Andrews S, Sumoreeah M, Sinclair LV, Howden AJM, Arthur JSC. eLife - Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation
Li Q, de Oliveira Formiga R, Puchois V, … , Argüello RJ, … , Michel ML, Wai T, Sokol H. Nature Metabolism - High-Risk neuroblastoma therapeutics Topotecan and 13-cis-Retinoic acid modulate autophagy and induce DNA damage response in hematopoietic stem cells and monocytes
Lázničková P, Tidu F, Hrdý J, Boráková K, Hortová Kohoutková M, Frič J. Scientific Reports - Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Alonso S, Kaur H, Jia L, Nguyen MU, Laguerta A, Fong A, Skariah N, Argüello RJ, Verzi MP, Swamy M, Lau KS, Edelblum KL. Mucosal Immunology - Single-cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions
Karra L, Finger AM, Shechtman L, Krush M, Meng-Yao Huang R, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. Blood Advances - Fatty acid binding protein 2 (FATP2/SLC27A2) blockade with Lipofermata elicits dual effects on inflammatory responses in human monocytes and macrophages
Hahn N, Chornyi S, Heister D, de Vries HE, Giera M, Boon MR, Kooij G, Van den Bossche J. Immunology Letters - Spatial immunometabolic zonation in tuberculosis granulomas
Sinha A, Weichhart T. Nature Reviews Immunology - In vivo itaconate tracing reveals degradation pathway and turnover kinetics
Willenbockel HF, Williams AT, Lucas A, Reynolds MB, Joulia E, Ruchhoeft ML, Dowerg B, Cabrales P, Metallo CM, Cordes T. Nature Metabolism
Commentary: A carbon trail to follow: unveiling itaconate’s metabolism in vivo
Anisov DE, Clayton SA, Nosenko MA. Immunometabolism - Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells
Wang YH, Wang L, Ho PC. EMBO Journal - A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells
Roubanis A, Hilaire M, Le Teuff M, Devergne O, Sparwasser T, Berod L, Salomon BL. Immunology & Cell Biology - The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses
Silva L, Almeida L, Al-Naimi F, Nascimento DC, Lopez Krol A, Damasceno LEA, Echchannaoui H, Alves-Filho JC, Berod L, Sparwasser T. European Journal of Immunology - TLR9-Driven S-Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets
Quiroz JN, Sielaff M, Kondrateva D, Boukhallouk F, Godoy GJ, Molina CR, Moonen B, Motran CC, Bogie J, Luján HD, Tenzer S, Sparwasser T, Berod L. European Journal of Immunology - cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy
Galán M, Fernández-Méndez L, Núñez V, Femenía-Muiña M, Figuera-Belmonte P, Moya-Ruiz E, Martínez-Cano S, Hernández-García E, Rodrigo-Tapias M, Rodríguez-Ronchel A, Relaño-Rupérez C, Wculek SK, Benguria A, Dopazo A, Henri S, Jo S, Liu TT, Malissen B, Murphy KM, Ramiro AR, Carregal-Romero S, Ruiz-Cabello J, Robles-Vera I, Sancho D. Circulation Research - Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages
Li X, Møller SH, Park J, …, Ho MC, Shen YC, Ho PC. Journal of Experimental Medicine - CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients
Cook MS, King E, Flaherty KR, Siddika K, Papa S, Benjamin R, Schurich A. Cell Reports - Imidazole propionate is a driver and therapeutic target in atherosclerosis
Mastrangelo A, Robles-Vera I, Mañanes D, …, Fuster V, Ibañez B, Sancho D. Nature - Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution
Papatheodorou I, Blažková G, Bosáková V, Tomášiková Z, Spearing E, Klieber R, Ostašov P, Štíchová J, Dvončová M, Mýtniková A, Emmer J, Bendíčková K, Tomáš T, Šrámek V, Kolovos P, Holubová M, Helán M, Vlková M, Frič J, Hortová-Kohoutková M. Journal of Translational Medicine - The source of dietary fat influences anti-tumour immunity in obese mice
Kunkemoeller B, Prendeville H, McIntyre C, Temesgen A, Loftus RM, Yao C, Dyck L, Sinclair LV, Rollings C, Douglas A, Pernes G, Mitchelson KAJ, Harmon C, Raverdeau M, Ward R, Kane H, Kline J, O’Brien KL, Brennan M, Smith F, Stevens B, Roche HM, Lavelle EC, Finlay DK, Cantrell DA, Chouchani ET, Kaech S, Mills EL, Haigis M, Lynch L. Nature Metabolism - PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis
Cetti F, Ossoli A, Garavaglia C, Da Dalt L, Norata GD, Gomaraschi M. Annals of Medicine - Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells
Teh MR, Gudgeon N, Frost JN, Sinclair LV, Smith AL, Millington CL, Kronsteiner B, Roberts J, Marzullo BP, Murray H, Preston AE, Stavrou V, Rehwinkel J, Milne TA, Tennant DA, Dunachie SJ, Armitage AE, Dimeloe S, Drakesmith H. Nature Communications - Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo I, Mañanes D, Munné P, Núñez V, Herrera J, Catalá-Montoro M, Alvarez M, Del Pozo MA, Melero I, Wculek SK, Sancho D. Nature Communications - Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer
Slattery K, Yao CH, Mylod E, Scanlan J, Scott B, Crowley JP, McGowan O, McManus G, Brennan M, O’Brien K, Glennon K, Corry E, Treacy A, Argüello RJ, Gardiner CM, Haigis MC, Brennan DJ, Lynch L. Science Immunology - Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
Kao YS, Lauterbach M, Lopez Krol A, Distler U, Godoy GJ, Klein M, Argüello RJ, Boukhallouk F, Vallejo Fuente S, Braband KL, Nurbekova A, Romero M, Mamareli P, Silva L, Damasceno LEA, Rampoldi F, Berod L, Lynch L, Hiller K, Sparwasser T. Nature Metabolism - ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance
Stüve P, Godoy GJ, Ferreyra FN, Hellriegel F, Boukhallouk F, Kao YS, More TH, Matthies AM, Akimova T, Abraham WR, Kaever V, Schmitz I, Hiller K, Lochner M, Salomon BL, Beier UH, Rehli M, Sparwasser T, Berod L. Molecular Metabolism - A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours
Pretto S, Yu Q, Bourdely P, Trusso Cafarello S, Van Acker HH, Verelst J, Richiardone E, Vanheer L, Roshanzadeh A, Schneppenheim F, Cresens C, Sassano ML, Dehairs J, Carion M, Ismail S, Agostinis P, Rocha S, Bald T, Swinnen J, Corbet C, Lunt SY, Thienpont B, Di Matteo M, Mazzone M. Nature Metabolism - Activated T cells break tumor immunosuppression by macrophage re-education
Trotta, R, Rivis, S., Zhao, S., Orban, M.P., Trusso Cafarello, S., Charatsidou, I., Poźniak, J., Dehairs, Vanheer L, Pulido Vicuña, C.A., Boecxstaens, V., Bechter, O., Bosisio, F.M., Swinnen, J.V., Marine, J.C., Mazzone, M. Cancer Discovery - Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis
Preston AE, Frost JN, Teh MR, Badat M, Armitage AE, Norfo R, Wideman SK, Hanifi M, White N, Roy NB, Babbs C, Ghesquiere B, Davies J, Howden AJ, Sinclair LV, Hughes JR, Kassouf M, Beagrie R, Higgs DR, Drakesmith H. Nature Communications - Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation
Griepke S, Grentzmann A, Tripodi GL, Hansen J, Fonseca MP, Nilsson MD, Tallouzi Y, Grupe E, Jensen PS, Beck HC, Temprano-Sagrera G, Sabater-Lleal M, Burton M, Dembic M, Thomassen M, Forteza MJ, Terp MG, Lindholt JS, Rasmussen LM, Steffensen LB, Stubbe J, Ketelhuth DFJ. Cardiovascular Research - Helminths target macrophage epigenetics and metabolism to evade immunity
Everts B. Trends in Parasitology - Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Sinclair LV, Youdale T, Spinelli L, Gakovic M, Langlands AJ, Pathak S, Howden AJM, Ganley IG, Cantrell DA. Nature Immunology - Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera I, Jarit-Cabanillas A, Brandi P, Martínez-López M, Martínez-Cano S, Rodrigo-Tapias M, Femenía-Muiña M, Redondo-Urzainqui A, Nuñez V, González-Correa C, Moleón J, Duarte J, Conejero L, Mata-Martínez P, Díez-Rivero CM, Bergón-Gutiérrez M, Fernández-López I, Gómez MJ, Quintas A, Dopazo A, Sánchez-Cabo F, Pariente E, Del Fresno C, Subiza JL, Iborra S, Sancho D. Immunity - Cross-priming in cancer immunology and immunotherapy
Luri-Rey C, Teijeira Á, Wculek SK, de Andrea C, Herrero C, Lopez-Janeiro A, Rodríguez-Ruiz ME, Heras I, Aggelakopoulou M, Berraondo P, Sancho D, Melero I. Nature Reviews Cancer
2024
- A call for accessible tools to unlock single-cell immunometabolism research
Cosgrove J, Marçais A, Hartmann FJ, Bergthaler A, Zanoni I, Corrado M, Perié L, Cabezas-Wallscheid N, Bousso P, Alexandrov T, Kielian T, Martínez-Martín N, Opitz CA, Lyssiotis CA, Argüello RJ, Van den Bossche J. Nature Metabolism - Understanding immunometabolism in cardiovascular disease: translating research into practice
Norata GD, Sancho D, Van den Bossche J, Ketelhuth DFJ on behalf of the European Immunometabolism Network (EIMN). European Heart Journal - Proceedings of EIMN’s 1st European Immunometabolism Conference
Ketelhuth DFJ, Desler C, Cordes T, Corrrado M, Argüello R, Everts B, Van den Bossche J on behalf of the European Immunometabolism Network (EIMN). Immunometabolism - Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia
Forte D, Pellegrino RM, Falvo P, Garcia-Gonzalez P, Alabed HBR, Maltoni F, Lombardi D, Bruno S, Barone M, Pasini F, Fabbri F, Vannini I, Donati B, Cristiano G, Sartor C, Ronzoni S, Ciarrocchi A, Buratta S, Urbanelli L, Emiliani C, Soverini S, Catani L, Bertolini F, Argüello RJ, Cavo M, Curti A. Nature Communications - Metabolic adaptation of myeloid cells in the glioblastoma microenvironment
Essakhi N, Bertucci A, Baeza-Kallee N, Colin C, Lavignolle-Heguy R, Garcia-Gonzalez P, Argüello RJ, Tchoghandjian A, Tabouret E. Frontiers in Immunology - CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction
Jankowski CSR, Weichhart T. Immunometabolism - Not just sugar: metabolic control of neutrophil development and effector functions
Ettel P, Weichhart T. Journal of Leukocyte Biology - Transferrin: the iron transporter takes control
Weichhart T. Blood - Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis
Maio M, Barros J, Joly M, … , Argüello RJ, … , Neyrolles O, Vérollet C, Balboa L. eLife - Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage crosstalk promoting immunosuppression and immunotherapy resistance
Scolaro T , Manco M, Pecqueux M, … , DasGupta R, Topal B, Mazzone M. Nature Cancer - Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis
Lim CX, Redl A, Kleissl L, Pandey RV, Mayerhofer C, El Jammal T, Mazic M, Gonzales K, Sukhbaatar N, Krausgruber T, Bock C, Hengstschläger M, Calender A, Pacheco Y, Stary G, Weichhart T. American Journal of Respiratory and Critical Care Medicine - Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls
Saha P, Ettel P, Weichhart T. Trends in Pharmacological Sciences - Metabolic homeostasis of tissue macrophages across the lifespan
Wculek SK, Forisch S, Miguel V, Sancho D. Trends in Endocrinology & Metabolism - Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
Nosenko M, Anisov D, Gubernatorova E, Gorshkova E, Zeng Y-R, Ye D, Wang P, Finlay D, Drutskaya M, Nedospasov S. Journal of Leukocyte Biology - Harnessing dendritic cell metabolism for healthy ageing: reducing the risk of cardiovascular disease?
Wculek SK. European Heart Journal - Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Heras-Murillo I, Adán-Barrientos I, Galán M, Wculek SK, Sancho D. Nature Reviews Clinical Oncology