1st European ImmunoMetabolism Conference
Metabolism Meets immunology
26-28 June, 2024
Comwell Køge Strand, Køge, Denmark
The inaugural European Immunometabolism Conference, organized by the European Immunometabolism Network (ImmunoMetEurope), took place in Køge, Denmark (Comwell Køge Strand), on the outskirts of Copenhagen, from June 26-28, 2024.
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Organized by:
European Immunometabolism Network
Chair: Daniel Ketelhuth – University of Southern Denmark
Co-Chair: Claus Desler – University of Copenhagen
Mauro Corrado – University of Cologne
Thekla Cordes – Technische Universität Braunschweig
Rafael J. Arguello – Center for Immunology of Marseille-Luminy
Sponsored by:
Supported by:
Program
Wednesday, June 26th
12:50 Welcome Address and a word from the Novo Nordisk Foundation
SESSION I – METABOLIC REGULATION OF INNATE IMMUNITY
Chairs: Luciana Berod (Germany) and David Finlay (Republic of Ireland)
13:10 Bart Everts (Leiden University Medical Center, Netherlands) – O-GlcNAcylation: Hitting the sweetspot of myeloid cells
13:30 Thomas Weichhart (Medical University of Vienna, Austria) – Metabolic regulation of tissue homeostasis by macrophages
13:50 David Sancho (Centro Nacional de Investigaciones Cardiovasculares, Spain) – Mitochondrial electron transport chain orchestrates dendritic cell function
14:10 Maria G. Ledesma-Colunga (Dresden University of Technology) – Parsing the role of transferrin receptor 2 on modulating metabolic changes in IFNg stimulated macrophages
14:20 Anna Parolini (Università degli Studi di Milano) – Neutrophil aging is actively involved in the immunometabolic response to high fat diet
14:30 Anouk Ewen (Luxembourg Institute of Health) – Beyond ubiquitination: Ubc13 in the core of mitochondrial regulation and innate immunity
14:40 Coffee Break
SESSION II – METABOLIC REGULATION OF ADAPTIVE IMMUNITY
Chairs: Anna Schurich (UK) and Giuseppe Danilo Norata (Italy)
15:10 Linda Sinclair (University of Dundee, Scotland) – Nutrient transport in T cells
15:30 Mauro Corrado (University of Cologne, Germany) – Systemic effects of metabolic deficiencies in T cells
15:50 Luciana Berod (University Medical Center Mainz, Germany) – Postranslational modifications at the crossroad between metabolism and immunity
16:10 Yu-San Kao (Johannes Gutenberg-University Mainz) – Targeting ACC1 in T cells ameliorates psoriatic skin inflammation
16:20 Megan Teh (University of Oxford) – Iron restricted CD8+ T-cells display metabolic perturbations and show sensitivity to aspartate supplementation
16:30 Simon Hirschberger (Ludwig-Maximilian-University) – Cytotoxic T-cell immunometabolic paralysis through stress-induced mitochondrial hyperfusion after
major surgery
16:40 Coffee Break
17:10 KEYNOTE SPEAKER 1
Chair: Thekla Cordes (Germany)
Christoph Hess (University of Cambridge) – Epstein Barr Virus – searching for a metabolic Achilles’ heel
19:30 Dinner
20:30 Posters and mingling (sponsored by somalogic)
Thursday, June 27th
SESSION III – IMMUNOMETABOLISM IN CANCER
Chair: Mauro Corrado (Germany) and Dirk Brenner (Luxembourg)
08:30 Anna Schurich (King’s College London, UK) – Metabolic regulation in CAR T cells
08:50 Massimiliano Mazzone (VIB-KU Leuven, Belgium) – Harnessing tumor metabolism to overcome immunosuppression
09:10 Per thor Straten (University of Copenhagen, Copenhagen) – The exercise of tinkering with the immune system
9:30 Sofie Hedlund Møller (Ludwig Institute of Cancer Research/Université de Lausanne) – IFN-I-mediated effector program of tumor-specific CD8+ T cells in the tumor draining lymph node
9:40 Karen Slattery (Trinity College Dublin) – Dysregulated lipid metabolism is a key driver of immunosuppression in ovarian cancer
9:50 Paulina Garcia-Gonzalez (Centre d’Immunologie de Marseille-Luminy) – Unraveling metabolic plasticity and epigenetic dynamics in acute myeloid leukemia: insights into therapeutic resistance and immune modulation
10:00 Coffee Break
SESSION IV – NEW TECHNOLOGIES AND TRANSLATIONAL APPROACHES
Chairs: Thomas Weichhart (Austria) and Bart Everts (Netherlands)
10:30 David Finlay (Trinity College, Dublin, Republic of Ireland) – Using Click chemistry to study nutrient uptake in single cells
10:50 Jan Van den Bossche (Amsterdam UMC, Netherlands) – Entering a second decade of macrophage immunometabolism research
11:10 Rafael José Argüello (Center of Immunology of Marseille Luminy, France) – Metabolism as a new layer in the single cell multi-omics field
11:30 Yarden Engel (The Hebrew University of Jerusalem) – Generating Metabolically Superior T Cells as a Novel Immunotherapy to Treat Solid Tumors
11:40 Birte Dowerg (TU Braunschweig) – Quantification of mitochondrial metabolism and fluxes in anchorage-independent cultures during viral infections
11:50 Kristine Bertheussen (Leiden University) – Quantifying oleic acid uptake at the single-cell level
12:00 Lunch Break (including group photo)
SESSION V – IMMUNOMETABOLISM IN CARDIOMETABOLIC DISEASES
Chairs: Linda Sinclair (Scotland) and David Sancho (Spain)
13:10 Soraya Taleb (Paris-Centre de Recherche Cardiovasculaire, Inserm, France) – Role of intestinal tryptophan metabolism in atherosclerosis
13:30 Giuseppe Danilo Norata (University of Milan, Italy) – Lipoproteins and lipid cell-specific metabolic checkpoints to modulate the immune response
13:50 Kate Lykke Lambertsen (University of Southern Denmark, Denmark) – The role of TNF in obesity and stroke
14:10 Gareth Purvis (University of Oxford) – Exposure to elevated cholesterol results in a non-reversible epigene6c and metabolic shi8 in macrophages associated with increased residual inflammatory risk.
14:20 Jakob Hansen (University of Southern Denmark) – Insights into the role of NPC2 in vascular inflammation and atherosclerosis
14:30 Aitor Jarit Cabanillas (CNIC-Spanish National Centre for Cardiovascular Diseases) – Calcineurin/NFAT signalling reprograms the epigenomic landscape during innate trained immunity
14:40 Coffee Break
15:10 Round Table – Diversity in Science and Career Perspectives
16.10 Short break
16:20 KEYNOTE SPEAKER 2
Chair: Claus Desler (Denmark)
Inge Marie Svane (University of Copenhagen, Denmark) – T cells fit for fighting cancer
19:30 Dinner
20:30 Posters and mingling (sponsored by somalogic)
Friday, June 28th
SESSION VI – IMMUNOMETABOLISM IN INFECTIONS
Chairs: Massimiliano Mazzone (Belgium) and Jan Van den Bossche (Netherlands)
08:30 Thekla Cordes (University of Braunschweig, Germany) – Signaling roles of mitochondrial metabolites influencing inflammation
08:50 Dirk Brenner (LIH & University of Luxembourg, Luxembourg) – cROSsroads: Bacterial Infections, Metabolic Adaptations of T Cells and Mucosal Immunity
09:10 Maxim Nosenko (Trinity College Dublin, Ireland) – Immunometabolic targeting of NK cells in bacterial infections and sepsis
09:30 Fran Prenen (Rega Institute for Medical Research) – JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice by preventing lethal hypoglycemia
09:40 Sheila Macharia (Lancaster University) – IgM is a regulator of pleural cavity macrophage metabolism
09:50 Graham Heieis (Leiden University Medical Center) – O-GlcNAcylation acts as a metabolic break to maintain macrophage residency
10:00 Coffee Break
10:30 KEYNOTE SPEAKER 3
Chair: Rafael José Argüello (France)
Elina Zuniga (University of California San Diego, USA) – Multi-system response to infection
11:30 Awards and closing remarks
12:00 Lunch
13:00 Departures
Speakers
Anna Schurich, King’s College London, UK
Bart Everts, Leiden University Medical Center, Netherlands
David Sancho, Centro Nacional de Investigaciones Cardiovasculares, Spain
Elina Zuniga, University of California San Diego, USA
Keynote speaker
Giuseppe Danilo Norata, University of Milan, Italy
Inge Marie Svane, University of Copenhagen, Denmark
Keynote speaker
Jan Van den Bossche, Amsterdam UMC, Netherlands
Luciana Berod, University Medical Center Mainz, Germany
Mauro Corrado, University of Cologne, Germany
Massimiliano Mazzone, VIB-KU Leuven, Belgium
Maxim Nosenko, Trinity College Dublin, Ireland
Rafael José Argüello, Center of Immunology of Marseille Luminy, France
Soraya Taleb, Paris-Centre de Recherche Cardiovasculaire, Inserm, France
Thekla Cordes, University of Braunschweig, Germany
Thomas Weichhart, Medical University of Vienna, Austria
Christoph Hess, University of Cambridge, UK
Keynote speaker
Kate Lykke Lambertsen, University of Southern Denmark, Denmark
Per Thor Straten, University of Copenhagen, Copenhagen
Linda Sinclair, University of Dundee, Scotland
Dirk Brenner, LIH & University of Luxembourg, Luxembourg
David Finlay, Trinity College, Dublin, Republic of Ireland
Venue
The 1st European Immunometabolism Conference 2024 is planned to be hosted at the Comwell Køge Strand Hotel, on the outskirts of Copenhagen (~40 min from Central Station), from June 26–28, 2024. Køge is a cosy and historic mediaeval town with many good shops, located within walking distance from the hotel.
Comwell Køge Strand is located by the beach and has an excellent location along Køge Brugt. The hotel has been newly renovated and radiates a pleasant atmosphere with a modern and inviting interior, like a beach hotel in a special class. Located only 45 km from Copenhagen, Comwell Køge Strand will be ideal for our academic agenda and scheduled events, as well as provide a peaceful setting that will encourage attendees to fully engage with the conference.
At Comwell Køge Strand, there are 127 well-furnished double rooms. The hotel is decorated in bright colours, like a modern beach hotel. For more information about the hotel, click here.
Address
Comwell Køge Strand
Strandvejen 111
4600 Køge
Denmark
Round Table – Diversity in Science and Career Perspectives
Join us for an insightful round table panel debate focusing on the dynamic field of immunometabolism. Our panelists, representing key entities such as granting bodies, scientific journals, biotech companies, and clinical crossovers, will discuss critical topics that shape the future of scientific careers.
Discussion Topics:
- The Future Potential and Challenges of Immunometabolism
- Diversity in the Field: Current and Future Opportunities and Challenges
- The Interconnectedness of Research Disciplines: Clinical, Basic Science, and Industry Perspectives
This debate aims to inspire and guide students and early-career scientists by showcasing diverse career paths and emphasizing the importance of interdisciplinary collaboration in advancing the field of immunometabolism.