Wednesday, June 26th
12:50 Welcome Address and a word from the Novo Nordisk Foundation
SESSION I – METABOLIC REGULATION OF INNATE IMMUNITY
Chairs: Luciana Berod (Germany) and David Finlay (Republic of Ireland)
13:10 Bart Everts (Leiden University Medical Center, Netherlands) – O-GlcNAcylation: Hitting the sweetspot of myeloid cells
13:30 Thomas Weichhart (Medical University of Vienna, Austria) – Metabolic regulation of tissue homeostasis by macrophages
13:50 David Sancho (Centro Nacional de Investigaciones Cardiovasculares, Spain) – Mitochondrial electron transport chain orchestrates dendritic cell function
14:10 Maria G. Ledesma-Colunga (Dresden University of Technology) – Parsing the role of transferrin receptor 2 on modulating metabolic changes in IFNg stimulated macrophages
14:20 Anna Parolini (Università degli Studi di Milano) – Neutrophil aging is actively involved in the immunometabolic response to high fat diet
14:30 Anouk Ewen (Luxembourg Institute of Health) – Beyond ubiquitination: Ubc13 in the core of mitochondrial regulation and innate immunity
14:40 Coffee Break
SESSION II – METABOLIC REGULATION OF ADAPTIVE IMMUNITY
Chairs: Anna Schurich (UK) and Giuseppe Danilo Norata (Italy)
15:10 Linda Sinclair (University of Dundee, Scotland) – Nutrient transport in T cells
15:30 Mauro Corrado (University of Cologne, Germany) – Systemic effects of metabolic deficiencies in T cells
15:50 Luciana Berod (University Medical Center Mainz, Germany) – Postranslational modifications at the crossroad between metabolism and immunity
16:10 Yu-San Kao (Johannes Gutenberg-University Mainz) – Targeting ACC1 in T cells ameliorates psoriatic skin inflammation
16:20 Megan Teh (University of Oxford) – Iron restricted CD8+ T-cells display metabolic perturbations and show sensitivity to aspartate supplementation
16:30 Simon Hirschberger (Ludwig-Maximilian-University) – Cytotoxic T-cell immunometabolic paralysis through stress-induced mitochondrial hyperfusion after
major surgery
16:40 Coffee Break
17:10 KEYNOTE SPEAKER 1
Chair: Thekla Cordes (Germany)
Christoph Hess (University of Cambridge) – Epstein Barr Virus – searching for a metabolic Achilles’ heel
19:30 Dinner
20:30 Posters and mingling (sponsored by somalogic)
Thursday, June 27th
SESSION III – IMMUNOMETABOLISM IN CANCER
Chair: Mauro Corrado (Germany) and Dirk Brenner (Luxembourg)
08:30 Anna Schurich (King’s College London, UK) – Metabolic regulation in CAR T cells
08:50 Massimiliano Mazzone (VIB-KU Leuven, Belgium) – Harnessing tumor metabolism to overcome immunosuppression
09:10 Per thor Straten (University of Copenhagen, Copenhagen) – The exercise of tinkering with the immune system
9:30 Sofie Hedlund Møller (Ludwig Institute of Cancer Research/Université de Lausanne) – IFN-I-mediated effector program of tumor-specific CD8+ T cells in the tumor draining lymph node
9:40 Karen Slattery (Trinity College Dublin) – Dysregulated lipid metabolism is a key driver of immunosuppression in ovarian cancer
9:50 Paulina Garcia-Gonzalez (Centre d’Immunologie de Marseille-Luminy) – Unraveling metabolic plasticity and epigenetic dynamics in acute myeloid leukemia: insights into therapeutic resistance and immune modulation
10:00 Coffee Break
SESSION IV – NEW TECHNOLOGIES AND TRANSLATIONAL APPROACHES
Chairs: Thomas Weichhart (Austria) and Bart Everts (Netherlands)
10:30 David Finlay (Trinity College, Dublin, Republic of Ireland) – Using Click chemistry to study nutrient uptake in single cells
10:50 Jan Van den Bossche (Amsterdam UMC, Netherlands) – Entering a second decade of macrophage immunometabolism research
11:10 Rafael José Argüello (Center of Immunology of Marseille Luminy, France) – Metabolism as a new layer in the single cell multi-omics field
11:30 Yarden Engel (The Hebrew University of Jerusalem) – Generating Metabolically Superior T Cells as a Novel Immunotherapy to Treat Solid Tumors
11:40 Birte Dowerg (TU Braunschweig) – Quantification of mitochondrial metabolism and fluxes in anchorage-independent cultures during viral infections
11:50 Kristine Bertheussen (Leiden University) – Quantifying oleic acid uptake at the single-cell level
12:00 Lunch Break (including group photo)
SESSION V – IMMUNOMETABOLISM IN CARDIOMETABOLIC DISEASES
Chairs: Linda Sinclair (Scotland) and David Sancho (Spain)
13:10 Soraya Taleb (Paris-Centre de Recherche Cardiovasculaire, Inserm, France) – Role of intestinal tryptophan metabolism in atherosclerosis
13:30 Giuseppe Danilo Norata (University of Milan, Italy) – Lipoproteins and lipid cell-specific metabolic checkpoints to modulate the immune response
13:50 Kate Lykke Lambertsen (University of Southern Denmark, Denmark) – The role of TNF in obesity and stroke
14:10 Gareth Purvis (University of Oxford) – Exposure to elevated cholesterol results in a non-reversible epigene6c and metabolic shi8 in macrophages associated with increased residual inflammatory risk.
14:20 Jakob Hansen (University of Southern Denmark) – Insights into the role of NPC2 in vascular inflammation and atherosclerosis
14:30 Aitor Jarit Cabanillas (CNIC-Spanish National Centre for Cardiovascular Diseases) – Calcineurin/NFAT signalling reprograms the epigenomic landscape during innate trained immunity
14:40 Coffee Break
15:10 Round Table – Diversity in Science and Career Perspectives
16.10 Short break
16:20 KEYNOTE SPEAKER 2
Chair: Claus Desler (Denmark)
Inge Marie Svane (University of Copenhagen, Denmark) – T cells fit for fighting cancer
19:30 Dinner
20:30 Posters and mingling (sponsored by somalogic)
Friday, June 28th
SESSION VI – IMMUNOMETABOLISM IN INFECTIONS
Chairs: Massimiliano Mazzone (Belgium) and Jan Van den Bossche (Netherlands)
08:30 Thekla Cordes (University of Braunschweig, Germany) – Signaling roles of mitochondrial metabolites influencing inflammation
08:50 Dirk Brenner (LIH & University of Luxembourg, Luxembourg) – cROSsroads: Bacterial Infections, Metabolic Adaptations of T Cells and Mucosal Immunity
09:10 Maxim Nosenko (Trinity College Dublin, Ireland) – Immunometabolic targeting of NK cells in bacterial infections and sepsis
09:30 Fran Prenen (Rega Institute for Medical Research) – JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice by preventing lethal hypoglycemia
09:40 Sheila Macharia (Lancaster University) – IgM is a regulator of pleural cavity macrophage metabolism
09:50 Graham Heieis (Leiden University Medical Center) – O-GlcNAcylation acts as a metabolic break to maintain macrophage residency
10:00 Coffee Break
10:30 KEYNOTE SPEAKER 3
Chair: Rafael José Argüello (France)
Elina Zuniga (University of California San Diego, USA) – Multi-system response to infection
11:30 Awards and closing remarks
12:00 Lunch
13:00 Departures