Biosketch
Maxim Nosenko has acquired his PhD in 2019 in the group of Prof. Sergei Nedospasov, EIMB, Moscow. He was working on the interdisciplinary project, combining immunology and bioengineering, employing silk-based biomaterials to harness immunity. During the PhD, he had several side projects focused on cytokines and inflammatory response, which eventually brought him into the field of immunometabolism.
In 2021 he has joined Prof. David Finlay group in Trinity College Dublin as a postdoctoral researcher working on NK cell metabolism in cancer. In 2023 he has obtained MSCA Postdoctoral Fellowship for the project TANK_Sepsis, investigating how alteration of amino acid availability during infection affects NK cells.
Research profile
During his PhD Maxim discovered that silk-based biomaterials can regulate inflammatory response of immune cells and even non-immune cells, such as fibroblasts and keratinocytes (30564244; 33817420).
Continuing the work on inflammation, he contributed to the development of cell-specific inhibitors of proinflammatory cytokines, generated from single-chain antibodies (33185870; 31779851; 28919896).
Early after PhD he has switched his focus towards interplay between inflammation and metabolism. He worked on metabolic functions of IL-6 during inflammation as well as regulation of proinflammatory cytokines with immunometabolites, such as itaconate.
Main research questions:
The focus of my research is the interplay between organismal and immune cell metabolism in the context of diseases. In particular, I work on following questions:
- How does tumor microenvironment affect metabolism of immune cells?
- What is the impact of systemic nutrients availability on immune response to infections?
- How do immunometabolites affect immune and non-immune cells?
Ongoing projects are focused on metabolic determinants of NK cell activation in the context of diseases. We use single-cell metabolic toolbox as well as multi-omics approach to study NK cell metabolism in tumor microenvironment in order to improve NK-based cancer immunotherapy. In TANK_Sepsis we investigate the idea that during infection the host can regulate activation of immune cells via controlling systemic availability of nutrients, such as amino acids. By using metabolic toolkits as well as mice with defective amino acid transport in NK cells, we dissect the link between organismal and cellular metabolism to provide new insights for treatment of sepsis.
Positions and training
2021 – present: Postdoctoral Researcher, Immunometabolism Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
2019-2021: Postdoctoral Researcher, Molecular Mechanisms of Immunity Lab, Engelhard Institute of Molecular Biology RAS, Moscow, Russia
2015 – 2019: PhD Student, Molecular Mechanisms of Immunity Lab, Engelhard Institute of Molecular Biology RAS, Moscow, Russia
Contributions
- Member of organizing committee for Global Immunometabolism Forum