Wednesday, June 26th, 2024

12:50 Welcome Address

SESSION I – METABOLIC REGULATION OF INNATE IMMUNITY 

13:10 Bart Everts (Leiden University Medical Center, Netherlands) – O-GlcNAcylation: Hitting the sweetspot of myeloid cells

13:30 Thomas Weichhart (Medical University of Vienna, Austria) – Metabolic regulation of tissue homeostasis by macrophages

13:50 David Sancho (Centro Nacional de Investigaciones Cardiovasculares, Spain) – Mitochondrial electron transport chain orchestrates dendritic cell function

14:10 Selected short oral presentations (1st part)

14:10 Maria G. Ledesma-Colunga (Dresden University of Technology) – Parsing the role of transferrin receptor 2 on modulating metabolic changes in IFNg stimulated macrophages

14:20 Anna Parolini (Università degli Studi di Milano) –  Neutrophil aging is actively involved in the immunometabolic response to high fat diet

14:30 Anouk Ewen (Luxembourg Institute of Health) – Beyond ubiquitination: Ubc13 in the core of mitochondrial regulation and innate immunity

14:40 Coffee Break

SESSION II – METABOLIC REGULATION OF ADAPTIVE IMMUNITY 

15:10 Linda Sinclair (University of Dundee, Scotland) – Nutrient transport in T cells

15:30 Mauro Corrado (University of Cologne, Germany) – Systemic effects of metabolic deficiencies in T cells

15:50 Luciana Berod (University Medical Center Mainz, Germany) – Postranslational modifications at the crossroad between metabolism and immunity

16:10 Selected short oral presentations (2nd part)

16:10 Yu-San Kao (Johannes Gutenberg-University Mainz) – Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

16:20 Megan Teh (University of Oxford) – Iron restricted CD8+ T-cells display metabolic perturbations and show sensitivity to aspartate supplementation 

16:30 Simon Hirschberger (Ludwig-Maximilian-University) – Cytotoxic T-cell immunometabolic paralysis through stress-induced mitochondrial hyperfusion after major surgery

16:40 Coffee Break

17:10 KEYNOTE SPEAKER 1 

Christoph Hess (University of Cambridge) – Epstein Barr Virus – searching for a metabolic Achilles’ heel

18.10 Dinner

19:30 Posters and mingling

Thursday, June 27th 2024

SESSION III – IMMUNOMETABOLISM IN CANCER

08:30 Anna Schurich (King’s College London, UK) – Metabolic regulation in CAR T cells

08:50 Massimiliano Mazzone (VIB-KU Leuven, Belgium) – Harnessing tumor metabolism to overcome immunosuppression

09:10 Per Thor Straten (University of Copenhagen, Copenhagen) – The exercise of tinkering with the immune system

09:30 Selected short oral presentations (3rd part)

9:30 Sofie Hedlund Møller (Ludwig Institute of Cancer Research/Université de Lausanne) – IFN-I-mediated effector program of tumor-specific CD8+ T cells in the tumordraining lymph node

9:40 Karen Slattery (Trinity College Dublin) – Dysregulated lipid metabolism is a key driver of immunosuppression in ovarian cancer

9:50 Paulina Garcia-Gonzalez (Centre d’Immunologie de Marseille-Luminy) – Unraveling metabolic plasticity and epigenetic dynamics in acute myeloid leukemia: insights into therapeutic resistance and immune modulation

10:00 Coffee Break

SESSION IV – NEW TECHNOLOGIES AND TRANSLATIONAL APPROACHES

10:30 David Finlay (Trinity College, Dublin, Republic of Ireland) –  Using Click chemistry to study nutrient uptake in single cells

10:50 Jan Van den Bossche (Amsterdam UMC, Netherlands) – Entering a second decade of macrophage immunometabolism research

11:10 Rafael José Argüello (Center of Immunology of Marseille Luminy, France) – Metabolism as a new layer in the single cell multi-omics field

11:30 Selected short oral presentations (4th part)

11:30 Yarden Engel (The Hebrew University of Jerusalem) – Generating Metabolically Superior T Cells as a Novel Immunotherapy to Treat Solid Tumors

11:40 Birte Dowerg (TU Braunschweig) – Quantification of mitochondrial metabolism and fluxes in anchorage-independent cultures during viral infections

11:50 Kristine Bertheussen (Leiden University) – Quantifying oleic acid uptake at the single-cell level

12:00 Lunch Break (including group photo)

SESSION V – IMMUNOMETABOLISM IN CARDIOMETABOLIC DISEASES

13:10 Soraya Taleb (Paris-Centre de Recherche Cardiovasculaire, Inserm, France) – Role of intestinal tryptophan metabolism in atherosclerosis

13:30 Giuseppe Danilo Norata (University of Milan, Italy) – Lipoproteins and lipid cell-specific metabolic checkpoints to modulate the immune response

13:50 Kate Lykke Lambertsen (University of Southern Denmark, Denmark) – The role of TNF in obesity and stroke

14:10 Selected short oral presentations (5th part)

14:10 Gareth Purvis (University of Oxford) – Exposure to elevated cholesterol results in a non-reversible epigene6c and metabolic shi8 in macrophages associated with increased residual inflammatory risk.

14:20 Jakob Hansen (University of Southern Denmark) – Insights into the role of NPC2 in vascular inflammation and atherosclerosis

14:30 Aitor Jarit Cabanillas (CNIC-Spanish National Centre for Cardiovascular Diseases) – Calcineurin/NFAT signalling reprograms the epigenomic landscape during innate trained immunity

14:40 Coffee Break

15:10 Round Table – Diversity in Science and Career Perspectives – [TBA]

16:10 European Immunometabolism Network – General Assembly

16:40 Coffee Break

17:10 KEYNOTE SPEAKER 2

Inge Marie Svane (University of Copenhagen, Denmark) – T-cells fit for fighting cancer

18.10 Dinner

19:30 Posters and mingling

Friday, June 28th, 2024

SESSION VI – IMMUNOMETABOLISM IN INFECTIONS

08:30 Thekla Cordes (University of Braunschweig, Germany) – Signaling roles of mitochondrial metabolites influencing inflammation

08:50 Dirk Brenner (LIH & University of Luxembourg, Luxembourg) – cROSsroads: Bacterial Infections, Metabolic Adaptations of T Cells and Mucosal Immunity

09:10 Maxim Nosenko (Trinity College Dublin, Ireland) – Immunometabolic targeting of NK cells in bacterial infections and sepsis

09:30 Selected short oral presentations (6th part)

09:30 Fran Prenen (Rega Institute for Medical Research) – JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice by preventing lethal hypoglycemia

09:40 Sheila Macharia (Lancaster University) – IgM is a regulator of pleural cavity macrophage metabolism

09:50 Graham Heieis (Leiden University Medical Center) – O-GlcNAcylation acts as a metabolic break to maintain macrophage residency

10:00 Coffee Break

10:30 KEYNOTE SPEAKER 3

Elina Zuniga (University of California San Diego, USA) – Multi-system response to infection

11:30 Awards and closing remarks

12:00 Lunch

13:00 Departures