Wednesday, June 26th

12:50 Welcome Address and a word from the Novo Nordisk Foundation

 

SESSION I – METABOLIC REGULATION OF INNATE IMMUNITY 

Chairs: Luciana Berod (Germany) and David Finlay (Republic of Ireland)

13:10   Bart Everts (Leiden University Medical Center, Netherlands) – O-GlcNAcylation: Hitting the sweetspot of myeloid cells

13:30   Thomas Weichhart (Medical University of Vienna, Austria) – Metabolic regulation of tissue homeostasis by macrophages

13:50   David Sancho (Centro Nacional de Investigaciones Cardiovasculares, Spain) – Mitochondrial electron transport chain orchestrates dendritic cell function

14:10   Maria G. Ledesma-Colunga (Dresden University of Technology) – Parsing the role of transferrin receptor 2 on modulating metabolic changes in IFNg stimulated   macrophages

14:20   Anna Parolini (Università degli Studi di Milano) – Neutrophil aging is actively involved in the immunometabolic response to high fat diet

14:30   Anouk Ewen (Luxembourg Institute of Health) – Beyond ubiquitination: Ubc13 in the core of mitochondrial regulation and innate immunity

 

14:40 Coffee Break

 

SESSION II – METABOLIC REGULATION OF ADAPTIVE IMMUNITY

Chairs: Anna Schurich (UK) and Giuseppe Danilo Norata (Italy)

15:10   Linda Sinclair (University of Dundee, Scotland) – Nutrient transport in T cells

15:30   Mauro Corrado (University of Cologne, Germany) – Systemic effects of metabolic deficiencies in T cells

15:50   Luciana Berod (University Medical Center Mainz, Germany) – Postranslational modifications at the crossroad between metabolism and immunity

16:10   Yu-San Kao (Johannes Gutenberg-University Mainz) – Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

16:20   Megan Teh (University of Oxford) – Iron restricted CD8+ T-cells display metabolic perturbations and show sensitivity to aspartate supplementation 

16:30   Simon Hirschberger (Ludwig-Maximilian-University) – Cytotoxic T-cell immunometabolic paralysis through stress-induced mitochondrial hyperfusion after 

            major surgery

 

16:40 Coffee Break

 

17:10 KEYNOTE SPEAKER 1

Chair: Thekla Cordes (Germany)

Christoph Hess (University of Cambridge) – Epstein Barr Virus – searching for a metabolic Achilles’ heel

 

19:30 Dinner

 

20:30 Posters and mingling

 

 

 

Thursday, June 27th

SESSION III – IMMUNOMETABOLISM IN CANCER

Chair: Mauro Corrado (Germany) and Dirk Brenner (Luxembourg)

08:30   Anna Schurich (King’s College London, UK) – Metabolic regulation in CAR T cells

08:50   Massimiliano Mazzone (VIB-KU Leuven, Belgium) – Harnessing tumor metabolism to overcome immunosuppression

09:10   Per thor Straten (University of Copenhagen, Copenhagen) – The exercise of tinkering with the immune system

9:30  Sofie Hedlund Møller (Ludwig Institute of Cancer Research/Université de Lausanne) – IFN-I-mediated effector program of tumor-specific CD8+ T cells in the         tumor draining lymph node

9:40  Karen Slattery (Trinity College Dublin) – Dysregulated lipid metabolism is a key driver of immunosuppression in ovarian cancer

9:50  Paulina Garcia-Gonzalez (Centre d’Immunologie de Marseille-Luminy) – Unraveling metabolic plasticity and epigenetic dynamics in acute myeloid leukemia:      insights into therapeutic resistance and immune modulation

 

10:00 Coffee Break

 

SESSION IV – NEW TECHNOLOGIES AND TRANSLATIONAL APPROACHES

Chairs: Thomas Weichhart (Austria) and Bart Everts (Netherlands)

10:30   David Finlay (Trinity College, Dublin, Republic of Ireland) – Using Click chemistry to study nutrient uptake in single cells

10:50   Jan Van den Bossche (Amsterdam UMC, Netherlands) – Entering a second decade of macrophage immunometabolism research

11:10   Rafael José Argüello (Center of Immunology of Marseille Luminy, France) – Metabolism as a new layer in the single cell multi-omics field

11:30   Yarden Engel (The Hebrew University of Jerusalem) – Generating Metabolically Superior T Cells as a Novel Immunotherapy to Treat Solid Tumors

11:40   Birte Dowerg (TU Braunschweig) – Quantification of mitochondrial metabolism and fluxes in anchorage-independent cultures during viral infections

11:50   Kristine Bertheussen (Leiden University) – Quantifying oleic acid uptake at the single-cell level

 

12:00 Lunch Break (including group photo)

 

SESSION V – IMMUNOMETABOLISM IN CARDIOMETABOLIC DISEASES

Chairs: Linda Sinclair (Scotland) and David Sancho (Spain)

13:10   Soraya Taleb (Paris-Centre de Recherche Cardiovasculaire, Inserm, France) – Role of intestinal tryptophan metabolism in atherosclerosis

13:30   Giuseppe Danilo Norata (University of Milan, Italy) – Lipoproteins and lipid cell-specific metabolic checkpoints to modulate the immune response

13:50   Kate Lykke Lambertsen (University of Southern Denmark, Denmark) – The role of TNF in obesity and stroke

14:10   Gareth Purvis (University of Oxford) – Exposure to elevated cholesterol results in a non-reversible epigene6c and metabolic shi8 in macrophages associated with increased residual inflammatory risk.

14:20   Jakob Hansen (University of Southern Denmark) – Insights into the role of NPC2 in vascular inflammation and atherosclerosis

14:30   Aitor Jarit Cabanillas (CNIC-Spanish National Centre for Cardiovascular Diseases) – Calcineurin/NFAT signalling reprograms the epigenomic landscape during innate trained immunity

 

14:40 Coffee Break

 

15:10  Round Table – Diversity in Science and Career Perspectives

 

16.10 Short break

 

16:20 KEYNOTE SPEAKER 2

Chair: Claus Desler (Denmark)

Inge Marie Svane (University of Copenhagen, Denmark) – T cells fit for fighting cancer

 

19:30 Dinner

 

20:30 Posters and mingling

 

Friday, June 28th

SESSION VI – IMMUNOMETABOLISM IN INFECTIONS

Chairs: Massimiliano Mazzone (Belgium) and Jan Van den Bossche (Netherlands)

08:30   Thekla Cordes (University of Braunschweig, Germany) – Signaling roles of mitochondrial metabolites influencing inflammation

08:50   Dirk Brenner (LIH & University of Luxembourg, Luxembourg) – cROSsroads: Bacterial Infections, Metabolic Adaptations of T Cells and Mucosal Immunity

09:10   Maxim Nosenko (Trinity College Dublin, Ireland) – Immunometabolic targeting of NK cells in bacterial infections and sepsis

09:30   Fran Prenen (Rega Institute for Medical Research) – JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice by preventing lethal hypoglycemia

09:40   Sheila Macharia (Lancaster University) – IgM is a regulator of pleural cavity macrophage metabolism

09:50   Graham Heieis (Leiden University Medical Center) – O-GlcNAcylation acts as a metabolic break to maintain macrophage residency

 

10:00 Coffee Break

 

10:30 KEYNOTE SPEAKER 3

Chair: Rafael José Argüello (France)

Elina Zuniga (University of California San Diego, USA) – Multi-system response to infection

 

11:30 Awards and closing remarks

 

12:00 Lunch

 

13:00 Departures